Moving forward
MVT has developed a new, patented formulation, MVT-100, for use as an ultrasound contrast agent, which has completed Phase II clinical trials.
MVT-100 has a neutral surface chemistry, potentially serving as a platform for development of agents for molecular imaging and image-guided therapy. We've received formal guidance from the FDA that MVT-100 can be developed via the 505(b)(2) pathway.
The Company has designed an accelerated development pathway to potentially lead to approval of MVT-100 for echocardiography.
Momentum with MVT–100
PHASE II Complete
MVT–100
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Indication:
Echocardiography
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505b Pathway — Accelerated approval. Patent granted for improved microbubble formulation.
PRE-CLINICAL
MVT–101
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Indication:
Ultrasound Mediated Tumor Ablation with Phase Shift Microbubble (PSMB) - Brain Cancer
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Nanobubbles are used in combination with Magnetic Resonance Guided Focused Ultrasound (MRgFUS) to perform non-thermal brain tumor ablation. Research is in partnership with the University of Utah and funded by the National Cancer Institute,
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• ISSUED PATENT
MVT–201
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Indication:
Sono​thrombolysis - Myocardial Microvascular Obstruction (MVO), Stroke, Deep Vein Thrombosis and Pulminary Embolism
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Thrombin-targeted nanobubbles supported by $4MM Department of Defense Grant.​
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MVT has right of reference to data showing efficacy of microbubble enhance sonothrombolysis using perflutren. MVT has exclusive right to condensed Phase Shift Microbubbles (PSMB).
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• ISSUED PATENT
MVT–301
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Indication:
Alzheimer's Disease
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Dissolution of amyloid plaques in Alzheimer's using proprietary nanobubbles and ultrasound.
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• ISSUED PATENT
• PATENT PENDING
MVT–401
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Indication:
Panc​reatic Cancer
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Detection of pancreatic cancers <1MM in size.
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• ISSUED PATENT
• IN-LICENCE
MVT–501
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Indication:
Breast Cancer​
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Improved detection and differentiation on routine breast ultrasound, enabling faster, more accurate, and cheaper detection and treatment of breast cancer.
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• ISSUED PATENT
MVT–601
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Indication:
Uveitis​
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E-selection targeted microbubble for the diagnosis of uveitis. Potential for drug delivery and treatment of macular degeneration.
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• ISSUED PATENT
• PATENT PENDING
